Cisplatin pulmonary toxicity

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WebToxicological effects of cisplatin are diverse and have been an area of concern for many oncologists, practitioners and researchers. Nausea and Vomiting are considered as the …

Cisplatin Side Effects: Common, Severe, Long Term

WebAug 1, 1998 · Cisplatin doses were fixed and were not reduced for any toxicity. The most common reasons for irinotecan dose reduction were nausea and vomiting (27% of patients), followed by diarrhea (21%), and neutropenia (12%). Response and Survival All patients were evaluated for response and survival. WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose limiting. greatest kiss picture disc

Cisplatin: Package Insert - Drugs.com

Webprimary pulmonary toxicity of cisplatin in cats. (Journal of Veterinary Internal Medicine. 1987; 129-35) CISPLATIN (cis-diamminedichloroplatinum) is a widely used … WebMyelosuppression is the most common toxicity of gemcitabine therapy. Pulmonary toxicities due to gemcitabine have, however, been reported. Dyspnea occurs in approximately 25% of patients treated with gemcitabine, whereas serious pulmonary toxicities are much less common, approximately 0.3%. WebDec 1, 2024 · Dose adjustments for both docetaxel and cisplatin were performed according to pre-defined criteria for each type of toxicity (mainly grade 4 neutropenia and grade 3–4 neuropathy). Two dose reductions were allowed for DC75 (first to 60 mg/m 2, second to 50 mg/m 2), but only 1 reduction was allowed for DC60 and DCM therapy (to 50 mg/m 2). … greatest king of france

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Pathophysiology of cisplatin-induced acute kidney injury

WebBased on 4448 patients, the incidences of dyspnea and other serious pulmonary toxicity were 0.45% and 0.27% respectively. Based on an estimated 217 400 patients treated with commercial gemcitabine worldwide, the crude incidences of dyspnea and other serious pulmonary toxicity were 0.02% and 0.06% respectively. WebThe TPF triplet regimen (docetaxel, cisplatin, and 5‐FU) has a trend of further improving treatment efficacy compared with the traditional doublet regimen. 35 , 36 In a phase II study, concurrent chemoradiotherapy with TPF achieved a clinical CR rate of 52.4%, much higher than the previously reported CR rate of 20%. 9 However, the high ... flipper bend signal mountainWebCisplatin is a platinum chemotherapeutic used in a variety of malignancies. The antineoplastic activity occurs from DNA cross-links and adducts, in addition to the … flipper band wikipedia

"WebFeb 14, 2008 · Cisplatin is a platinum chemotherapeutic used in a variety of malignancies. The antineoplastic activity occurs from DNA cross-links and adducts, in addition to the … " - Cisplatin pulmonary toxicity

Cisplatin pulmonary toxicity

Pulmonary toxicity associated with antineoplastic therapy …

WebToxicity is progressive, occurring over the course of weeks to months. The most strongly associated predictor of neurotoxicity is dose and cases occur with doses approaching 40 mg/m2. Diagnosis... WebFeb 11, 2024 · Cisplatin is a cytotoxic drug that triggers several toxicities. However, nephrotoxicity and ototoxicity remain major clinical limitations. The aim of our study was …

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WebFeb 2, 2024 · Cisplatin can cause not only nephrotoxicity but also cause severe neurotoxicity, which significantly limits its clinical use. A study showed that a continuous high dose of cisplatin stimulation disrupted the blood-brain barrier, leading to brain cell edema and neuronal necrosis (Namikawa et al., 2000). Regarding the study of prevention and ... WebApr 26, 2024 · To assess the prognostic impact of BPT, we retrospectively identified 52 patients who underwent bleomycin etoposide and cisplatin chemotherapy from 2008 to 2024 in our institution, and evaluated the risk factors of BPT and its effect on prognosis. Patients who had received chemotherapy at another institution were excluded.

WebMay 9, 2024 · A general discussion of the clinical presentation, pathogenesis, diagnosis, differential diagnosis, and management of antineoplastic agent-induced pulmonary toxicity is covered elsewhere, as is lung toxicity associated with molecularly targeted … WebRenal toxicity is a prominent component of the toxicity profile of platinum-based chemotherapy. Kidney damage, once dose limiting for cisplatin, occurs in some patients who receive carboplatin and may occur with the third-generation platinum analog ormaplatin.

WebSep 4, 2013 · The short hydration is safe without severe renal toxicities in regimens containing cisplatin (≥75 mg/m 2) for patients with lung cancer. short hydration, magnesium supplementation, cisplatin, lung cancer, renal toxicity Topic: chemotherapy regimen cisplatin creatinine kidney failure mannitol safety kidney lung cancer pemetrexed toxic … WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in …

WebApr 8, 2013 · Cisplatin reduces the renal clearance of bleomycin and in doing so may enhance toxicity [ 5 ]. 3. Common Side Effects Skin reactions are the most common side effects and include erythema, …

WebPulmonary toxicity of cytotoxic agents Platinum compounds The administration of cisplatin and carboplatin, the 2 most commonly used platinum derivative agents, can … flipper bend subdivisionWebNov 26, 2024 · Cisplatin-Induced Toxicity . Cisplatin, cis- diamine-dichloro-platinum (CDDP) is one of the most used chemotherapy drugs because it is effective against different types of tumors. ... Mediators such as 4-HNE and H 2 O 2 are among the most relevant secondary messengers induced by ozone during lung toxicity following airway … greatest kiss albumWebIn group 1, cisplatin was administered at a dose of 60 mg/m2 to four cats. In an attempt to avoid renal toxicity, saline diuresis was induced by administering 0.9% saline solution … greatest knights in historyWebJan 12, 2024 · Cisplatin has severe nonhematological toxicities, particularly nephrotoxicity and gastrointestinal toxicity. The recent development of new antiemetic therapies has greatly reduced... greatest knockouts in boxingWebcancer with Cisplatin is 95% with a 25 year risk of cardiovascular toxicity in 16% patients due to direct endothelial damage of Cisplatin or indirectly induced hormonal and … greatest kings of spainWebPubMed Central (PMC) flipper bend signal mountain tnWebMar 29, 2015 · Cisplatin-based regimens are associated with enhanced efficacy and toxicity as compared with carboplatin-based therapy 32,33; yet in CALGB protocol 9633, 27 33 percent of patients required dose... greatest knicks players of all time