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WebNational Center for Biotechnology Information WebIntroduction. What is the genetic cause of Alzheimer’s disease (AD)? The answer to this question has not changed much for the past decade. 10–20% of early-onset familial forms of AD are caused by mutations in APP, PSEN1, and PSEN2 (Tanzi et al., 1987; Levy-Lahad et al., 1995; Sherrington et al., 1995). Genome-wide association studies (GWASs) have … binary tree traversal function
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